GENE THERAPY For Kidney Rescue
Klotho
Klotho has been called the king of anti-aging proteins. For years its absence has been known to contribute to Chronic Kidney Disease, but research now has turned to its broader role in the aging process as a whole.
Inducing Klotho expression with gene therapy in mice lengthens their lifespans by targeting many of the same pathways as caloric restriction. Knocking it out, on the other hand, causes premature aging. It not only protects the brain, but contributes more to differences in intelligence than any single gene.
Research by a group at the University of California showed Klotho protected the brains of mice and improved their brain function within four hours - this included young mice, old mice, and those bred to serve as a model for Alzheimer's Disease. It also plays a critical role in the inflammaging process, Dr. Lei Zu states:
"The barrier between the brain and the immune system seems to break down with low levels of Klotho. Our findings indicate that Klotho helps keep that barrier closed. When levels of this molecule are depleted in the choroid plexus, the barrier becomes more porous and allows immune cells and inflammatory molecules to get through more easily.”
SMALL DOG Kidney
$17,000
EXTEND THE HEALTHY LIFE TO YOUR PET.
Dogs 2-10 pounds
MEDIUM DOG Kidney
$25,000
EXTEND THE HEALTHY LIFE TO YOUR PET.
Dogs 10-60 pounds - inquire about larger breeds
$65,000 and up for dogs over 80 pounds
LARGE DOG Kidney
$25,000
CAT Kidney
$18,000
EXTEND THE HEALTHY LIFE TO YOUR PET.
Owner must arrange travel and boarding
HORSE Kidney
$150,000
Owner must arrange travel and boarding
References
“Klotho as a potential biomarker and therapy for acute kidney injury” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3752896/ Ming-Chang Hu and Orson W. Moe
“Amelioration of progressive renal injury by genetic manipulation of Klotho gene” http://www.pnas.org/content/104/7/2331 Yoshisuke Haruna, Naoki Kashihara, Minoru Satoh, Naruya Tomita, Tamehachi Namikoshi, Tamaki Sasaki, Toshihiko Fujimori, Ping Xie, and Yashpal S. Kanwar
“Klotho and Chronic Kidney Disease” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3911771/ Ming Chang Hu, MD, PhD,1,2,4 Makoto Kuro-o, MD, PhD,1,5 and Orson W. Moe, MD1,2,3
“Klotho to Treat Kidney Fibrosis”- http://jasn.asnjournals.org/content/24/5/687.full Correspondence: Dr. Alberto Ortiz, Unidad de Diálisis, Fundación Jiménez Díaz, Av Reyes Católicos 2, 28040 Madrid, Spain. Email: aortiz{at}fjd.es
“Effects of Klotho on fibrosis and cancer: A renal focus on mechanisms and therapeutic strategies” https://www.sciencedirect.com/science/article/pii/S0169409X17301060 Rik Menckea Hannes Olausonb Jan-Luuk Hillebrandsa
“Klotho preservation via histone deacetylase inhibition attenuates chronic kidney disease-associated bone injury in mice” https://www.nature.com/articles/srep46195
Wenjun Lin, Yanning Li, Fang chen, Shasha Yin , Zhihong Liu & Wangsen Cao
“Variation in longevity gene klotho is associated with greater cortical volumes”. Annals Clin. Trans. Neurology” https://www.ncbi.nlm.nih.gov/pubmed/25815349 Yokoyama JS et al., (Jan 2015).
“Suppression of aging in mice by the hormone Klotho”. https://www.ncbi.nlm.nih.gov/pubmed/16123266 Science. Kurosu H et al., (Sep 2005)
“Regulation of oxidative stress by the anti-aging hormone klotho.“
https://www.ncbi.nlm.nih.gov/pubmed/16123266 Yamamoto M1, Clark JD, Pastor JV, Gurnani P, Nandi A, Kurosu H, Miyoshi M, Ogawa Y, Castrillon DH, Rosenblatt KP, Kuro-o M.